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MDR1 in the Silken Windhound: A Sighthound Carrying a Herding Breed’s Mutation at 28.1%

Bottom line: The Silken Windhound is a sighthound, not a herding dog — and yet it carries the MDR1 (ABCB1-1Δ) mutation a...
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Spinocerebellar Ataxia in the Parson Russell Terrier (KCNJ10): Two Ataxias, Two Genes, and Why One Test Does Not Clear Your Dog

Bottom line: The Parson Russell Terrier carries two genetically separate inherited ataxias, and clearing your dog for on...
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Malignant Hyperthermia in the Greyhound (RYR1): What the Breed’s Anesthesia Reputation Actually Refers To

Bottom line: Greyhounds are the one breed with a genuine, evidence-backed reputation for anesthetic trouble — but most o...
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Lafora Disease in the Pembroke Welsh Corgi (NHLRC1): One Confirmed Case, No Measured Frequency — and Why a Linkage Test Isn’t Enough

Bottom line: Lafora disease is caused by a dodecamer (12-base) repeat expansion in NHLRC1, and it has been confirmed in ...
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Basset Hound Chondrodystrophy (CDDY) and Type I IVDD: What the FGF4 Retrogene Data Actually Show

Bottom line: In Basset Hounds, the short legs and the disc problems come from two different mutations, and only one of t...
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Staffordshire Bull Terrier Hereditary Cataract and the HSF4 Gene: What the Research Shows About Early-Onset Cataract

Bottom line: Early-onset hereditary cataract (HC) in the Staffordshire Bull Terrier is caused by an insertion in the HSF...
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Staffordshire Bull Terrier NCL and the ARSG Gene: What the Research Shows About This Late-Onset Neurological Disease

Bottom line: Neuronal ceroid lipofuscinosis (NCL) of the NCL-4A type is linked to a variant in the ARSG gene (p.R99H), i...
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Australian Cattle Dog NCL and the ATP13A2 Gene: What the Research Shows About This Late-Onset Neurological Disease

Bottom line: Late-onset neuronal ceroid lipofuscinosis (NCL) in the Australian Cattle Dog (Blue/Red Heeler) is caused by...
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Chihuahua and Neuronal Ceroid Lipofuscinosis (NCL / MFSD8·CLN7): What a DNA Test Can and Can’t Tell You

Conclusion: Neuronal ceroid lipofuscinosis (NCL) in Chihuahuas is reported to be caused by the MFSD8 (CLN7) variant c.84...
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English Setter and Neuronal Ceroid Lipofuscinosis (NCL/CLN8): What the DNA Test Can and Can’t Tell You

Bottom line: Neuronal ceroid lipofuscinosis (NCL) in the English Setter is an inherited, incurable brain disease associa...