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Rough Collie and Collie Eye Anomaly (CEA/NHEJ1): What the DNA Test Can and Can’t Tell You

In short: The Rough Collie is the breed most associated with Collie Eye Anomaly (CEA) and carries the highest known muta...
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Dog & Cat DNA Test Services: Which Variants Each One Actually Tests (33-Service Official Survey)

In short: We checked the official test catalog of every service one by one — 22 dog + 11 cat services (33 total) — to re...
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Gordon Setter & Late-Onset PRA (rcd4 / C2orf71): Why a Clear Eye Exam at Three Isn’t the Whole Story

The short answer: rcd4-PRA in the Gordon Setter is an inherited retinal disease caused by the C2orf71 (PCARE) c.3149_315...
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Alaskan Malamute GM1 Gangliosidosis (GLB1): What the Carrier Test Means for Breeders

The short answer: GM1 gangliosidosis is a severe, early-onset, fatal lysosomal storage disease with no cure, and the DNA...
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Portuguese Water Dog & PRA (prcd): What the DNA Test Covers — and the Second PRA Gene It Doesn’t

The short answer: prcd-PRA (progressive rod-cone degeneration) is a late-onset, inherited form of progressive retinal at...
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American Bulldog Ichthyosis (NIPAL4): What the DNA Test Really Tells You — Carrier vs. Affected

The short answer: Ichthyosis in the American Bulldog is an inherited skin-barrier disorder caused by a recessive variant...
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Wire Fox Terrier & Degenerative Myelopathy (SOD1): Why ~94% Carry the Risk Allele — and Why That Isn’t a Diagnosis

The short answer: A "genetically at-risk" SOD1 result for a Wire Fox Terrier is a risk factor, not a diagnosis — it tell...
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Phosphofructokinase (PFK-M) Deficiency in English Springer Spaniels (PFKM): What the Research Actually Shows

The English Springer Spaniel is the anchor breed in which canine muscle-type phosphofructokinase (PFK-M) deficiency, als...
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Factor VII Deficiency in Beagles (F7): What the Research Actually Shows — and Why It’s Usually Mild

The short answer: Factor VII (FVII) deficiency is an inherited, autosomal-recessive trait in Beagles caused by one varia...
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Cavalier King Charles Spaniel Macrothrombocytopenia (TUBB1): Big Platelets, Low Count, No Bleeding — Why It’s Often Misdiagnosed

The short answer: The Cavalier King Charles Spaniel is the founder breed for inherited macrothrombocytopenia caused by t...