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Miniature Bull Terrier and Primary Lens Luxation: What the ADAMTS17 Gene Test Really Shows

Conclusion: In the Miniature Bull Terrier, Primary Lens Luxation (PLL) is caused by a splice-site mutation in the ADAMTS...
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Lancashire Heeler and Collie Eye Anomaly: What the NHEJ1 Gene Test Really Shows

Conclusion: In the Lancashire Heeler, Collie Eye Anomaly (CEA) traces to a 7.8-kb deletion near the NHEJ1 gene, first ma...
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Chesapeake Bay Retriever SOD1 Test: One of the 5 Breeds That Defined Canine ALS Research

The short answer: The Chesapeake Bay Retriever was one of the five founding breeds in the 2009 study that first identifi...
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Long-Haired Whippet MDR1 Drug Sensitivity: WSU’s 50% Rate, Symptoms, and the $70 DNA Test

The short answer: Long-haired Whippets carry the MDR1 (ABCB1) mutation at a documented rate of about 50%, according to W...
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Copper Toxicosis (COMMD1) in Bedlington Terriers: What the DNA Test Can and Can’t Tell You

The short answer: COMMD1 is the gene where Bedlington Terrier copper toxicosis was first mapped, and it's still an autos...
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prcd-PRA (PRCD) in Miniature Poodles: Why This Variety Sits Under a Different Testing Standard

Conclusion: prcd-PRA is a single-variant, autosomal-recessive retinal disease first mapped by Zangerl et al. (2006, Geno...
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Malignant Hyperthermia (RYR1) in Pointers: What a Thin Evidence Trail Still Means for Anesthesia Safety

Conclusion: Malignant hyperthermia (MH) in dogs is a rare, autosomal-dominant reaction to specific anesthetic drugs, not...
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Lafora Disease (NHLRC1) in the Newfoundland: What the First Confirmed Case Means for This Mid-Popularity Breed

Conclusion: In 2021, veterinary geneticists reported the first confirmed Newfoundland with Lafora disease — a dog whose ...
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Dermatosparaxis Ehlers-Danlos Syndrome (ADAMTS2) in the American Pit Bull Terrier: What the Research Shows About This Rare Skin-Fragility Disorder

Conclusion: A frameshift variant in the ADAMTS2 gene (c.2280117delC) causes severe, sometimes fatal skin fragility — der...
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Globoid Cell Leukodystrophy (Krabbe Disease) in the West Highland White Terrier: The GALC Mutation Westies Share With Cairn Terriers

Conclusion: West Highland White Terriers can carry globoid cell leukodystrophy (GCL, also called Krabbe disease), caused...