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Alaskan Husky Cone Degeneration: What Sled Dog DNA Studies Show

Bottom line: The CNGB3 deletion that causes cone degeneration (day blindness) has been confirmed in Alaskan sled dogs, b...
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Toyger PK Deficiency: Why Research Has Data on Only 13 Cats

Bottom line: The Toyger appears on the PK deficiency testing lists of UC Davis and Langford (University of Bristol), but...
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Shih Tzu CDDY Test: What UC Davis Research Says About Disc Surgery Risk

Bottom line: In the Shih Tzu, the disc-disease variant CDDY (an FGF4 retrogene on chromosome 12) is present in some dogs...
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Muscular Dystrophy in the Cavalier King Charles Spaniel (DMD): Why a Clear Result Can Still Cover Only One of Two Variants

Bottom line: A clear commercial DNA result does not clear a Cavalier King Charles Spaniel of dystrophin-deficient muscul...
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CDDY in the Beagle: The Disc-Disease Retrogene Without the Short Legs

Bottom line: The Beagle carries the disc-disease allele without the dwarfism allele. Dogs have two FGF4 retrogenes: the ...
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Pyruvate Kinase Deficiency in the Beagle: Why PKLR Testing Is Breed-Specific

Bottom line: The Beagle has its own pyruvate kinase mutation — PKLR c.994G>A, p.(G332S), a missense change in exon 8 — a...
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Primary Lens Luxation in the American Hairless Terrier: What an ADAMTS17 Result Can and Cannot Predict

Bottom line: The American Hairless Terrier is one of the 23 breeds the Orthopedic Foundation for Animals lists for the A...
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Black Russian Terrier and Hyperuricosuria (HUU): What the SLC2A9 Gene Test Really Shows

Bottom line: Hyperuricosuria (HUU) in the Black Russian Terrier traces to the same exon-5 mutation in the SLC2A9 gene fi...
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Hyperuricosuria (HUU/SLC2A9) in the Dalmatian: Why the Whole Breed Carries It, and What the LUA Backcross Changed

Bottom line: Hyperuricosuria (HUU) is an autosomal recessive disorder caused by mutations in SLC2A9, the gene for a kidn...
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Nova Scotia Duck Tolling Retriever and Collie Eye Anomaly (CEA): What the NHEJ1 Gene Test Really Shows

Conclusion: In the Nova Scotia Duck Tolling Retriever, Collie Eye Anomaly (CEA) traces to the same NHEJ1 gene deletion i...